Fig. 2. Loss of miRNA-22 prevents obesogenic diet-induced dyslipidemia and insulin resistance in females. (A) Plasma triglycerides levels and (B) total cholesterol levels in WT and miR-22 KO females (n=5-8). (C) Analysis of intraperitoneal glucose tolerance test (iGTT) and (D) area under the curve (AUC) (n=7-12). (E) Insulin tolerance test (ITT) and (F) blood glucose disappearance rate (KITT) (n=4-9). (G) Activity of CPT1 in gastrocnemius muscle (n=5-9). (H) Relative protein levels of ALDH2 in gastrocnemius muscle of the mice (n=4-9). * WT obesogenic diet vs WT chow diet (p<0.05); # KO obesogenic diet vs KO chow diet (p<0.05); & KO obesogenic diet vs WT obesogenic diet (p<0.05).